Correlation of Solubility Thermodynamics of Glibenclamide with Recrystallization and In Vitro Release Profile

The solubility of glibenclamide was evaluated in DMSO, NMP, 1,4-dioxane, PEG 400, Transcutol(®) HP, water, and aqueous mixtures (T = 293.15~323.15 K). It was then recrystallized to solvate and compressed into tablets, of which 30-day stability and dissolution was studied. It had a higher solubility...

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Detalles Bibliográficos
Autores principales: Maharjan, Ravi, Jeong, Junoh, Bhujel, Ripesh, Kim, Min-Soo, Han, Hyo-Kyung, Kim, Nam Ah, Jeong, Seong Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874636/
https://www.ncbi.nlm.nih.gov/pubmed/35209181
http://dx.doi.org/10.3390/molecules27041392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874636/
https://www.ncbi.nlm.nih.gov/pubmed/35209181
http://dx.doi.org/10.3390/molecules27041392

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