Tyrphostin AG1024 Suppresses Coronaviral Replication by Downregulating JAK1 via an IR/IGF-1R Independent Proteolysis Mediated by Ndfip1/2_NEDD4-like E3 Ligase Itch

JAK1 depletion or downregulation was previously reported to account for coronavirus inhibition. Here, we found that AG1024, an IR (insulin receptor) and IGF-1R (insulin-like growth factor 1 receptor) inhibitor, diminishes JAK1 protein levels and exerts anti-coronaviral activities with EC(50) values...

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Detalles Bibliográficos
Autores principales: Yang, Cheng-Wei, Lee, Yue-Zhi, Hsu, Hsing-Yu, Zhao, Guan-Hao, Lee, Shiow-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874713/
https://www.ncbi.nlm.nih.gov/pubmed/35215353
http://dx.doi.org/10.3390/ph15020241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874713/
https://www.ncbi.nlm.nih.gov/pubmed/35215353
http://dx.doi.org/10.3390/ph15020241

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