Automated Flow Synthesis of Peptide–PNA Conjugates

[Image: see text] Antisense peptide nucleic acids (PNAs) have yet to translate to the clinic because of poor cellular uptake, limited solubility, and rapid elimination. Cell-penetrating peptides (CPPs) covalently attached to PNAs may facilitate clinical development by improving uptake into cells. We...

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Detalles Bibliográficos
Autores principales: Li, Chengxi, Callahan, Alex J., Phadke, Kruttika S., Bellaire, Bryan, Farquhar, Charlotte E., Zhang, Genwei, Schissel, Carly K., Mijalis, Alexander J., Hartrampf, Nina, Loas, Andrei, Verhoeven, David E., Pentelute, Bradley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874765/
https://www.ncbi.nlm.nih.gov/pubmed/35233452
http://dx.doi.org/10.1021/acscentsci.1c01019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874765/
https://www.ncbi.nlm.nih.gov/pubmed/35233452
http://dx.doi.org/10.1021/acscentsci.1c01019

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