Improved Cell-Potent and Selective Peptidomimetic Inhibitors of Protein N-Terminal Methyltransferase 1

Protein N-terminal methyltransferase 1 (NTMT1) recognizes a unique N-terminal X-P-K/R motif (X represents any amino acid other than D/E) and transfers 1–3 methyl groups to the N-terminal region of its substrates. Guided by the co-crystal structures of NTMT1 in complex with the previously reported pe...

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Detalles Bibliográficos
Autores principales: Dong, Guangping, Iyamu, Iredia D., Vilseck, Jonah Z., Chen, Dongxing, Huang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874984/
https://www.ncbi.nlm.nih.gov/pubmed/35209173
http://dx.doi.org/10.3390/molecules27041381

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8874984/
https://www.ncbi.nlm.nih.gov/pubmed/35209173
http://dx.doi.org/10.3390/molecules27041381

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