IBtkα Activates the β-Catenin-Dependent Transcription of MYC through Ubiquitylation and Proteasomal Degradation of GSK3β in Cancerous B Cells

The IBTK gene encodes the IBtkα protein that is a substrate receptor of E3 ubiquitin ligase, Cullin 3. We have previously reported the pro-tumorigenic activity of Ibtk in MYC-dependent B-lymphomagenesis observed in Eμ-myc transgenic mice. Here, we provide mechanistic evidence of the functional inter...

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Detalles Bibliográficos
Autores principales: Vecchio, Eleonora, Nisticò, Nancy, Golino, Gaetanina, Iaccino, Enrico, Maisano, Domenico, Mimmi, Selena, Aloisio, Annamaria, Renna, Maurizio, Avagliano, Angelica, Arcucci, Alessandro, Fiume, Giuseppe, Quinto, Ileana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875111/
https://www.ncbi.nlm.nih.gov/pubmed/35216159
http://dx.doi.org/10.3390/ijms23042044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875111/
https://www.ncbi.nlm.nih.gov/pubmed/35216159
http://dx.doi.org/10.3390/ijms23042044

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