Mechanistically Coupled PK (MCPK) Model to Describe Enzyme Induction and Occupancy Dependent DDI of Dabrafenib Metabolism

Dabrafenib inhibits the cell proliferation of metastatic melanoma with the oncogenic BRAF(V600)-mutation. However, dabrafenib monotherapy is associated with pERK reactivation, drug resistance, and consequential relapse. A clinical drug-dose determination study shows increased pERK levels upon daily...

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Detalles Bibliográficos
Autores principales: Albrecht, Marco, Kogan, Yuri, Kulms, Dagmar, Sauter, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875124/
https://www.ncbi.nlm.nih.gov/pubmed/35214043
http://dx.doi.org/10.3390/pharmaceutics14020310

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875124/
https://www.ncbi.nlm.nih.gov/pubmed/35214043
http://dx.doi.org/10.3390/pharmaceutics14020310

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