Evaluation of the Potency of Anti-HIV and Anti-HCV Drugs to Inhibit P-Glycoprotein Mediated Efflux of Digoxin in Caco-2 Cell Line and Human Precision-Cut Intestinal Slices

The inhibition of P-glycoprotein (ABCB1) could lead to increased drug plasma concentrations and hence increase drug toxicity. The evaluation of a drug’s ability to inhibit ABCB1 is complicated by the presence of several transport-competent sites within the ABCB1 binding pocket, making it difficult t...

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Detalles Bibliográficos
Autores principales: Huličiak, Martin, Vokřál, Ivan, Holas, Ondřej, Martinec, Ondřej, Štaud, František, Červený, Lukáš
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875242/
https://www.ncbi.nlm.nih.gov/pubmed/35215354
http://dx.doi.org/10.3390/ph15020242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875242/
https://www.ncbi.nlm.nih.gov/pubmed/35215354
http://dx.doi.org/10.3390/ph15020242

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