An Attenuated HSV-1-Derived Malaria Vaccine Expressing Liver-Stage Exported Proteins Induces Sterilizing Protection against Infectious Sporozoite Challenge

Here, we present the construction of an attenuated herpes simplex virus type-1 (HSV-1)-vectored vaccine, expressing three liver-stage (LS) malaria parasite exported proteins (EXP1, UIS3 and TMP21) as fusion proteins with the VP26 viral capsid protein. Intramuscular and subcutaneous immunizations of...

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Detalles Bibliográficos
Autores principales: Rider, Paul J. F., Kamil, Mohd, Yilmaz, Ilknur, Atmaca, Habibe N., Kalkan-Yazici, Merve, Ziya Doymaz, Mehmet, Kousoulas, Konstantin G., Aly, Ahmed S. I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875294/
https://www.ncbi.nlm.nih.gov/pubmed/35214758
http://dx.doi.org/10.3390/vaccines10020300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875294/
https://www.ncbi.nlm.nih.gov/pubmed/35214758
http://dx.doi.org/10.3390/vaccines10020300

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