Design, Synthesis and Structure-Activity Relationship Studies of Meridianin Derivatives as Novel JAK/STAT3 Signaling Inhibitors

Hyperactivation of Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling is an attractive therapeutic target for tumor therapy. Herein, forty-eight novel meridianin derivatives were designed and synthesized, and their antitumor activity was evaluated in vitro both f...

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Detalles Bibliográficos
Autores principales: Zhang, Jian-Qiang, Li, Rui, Dong, Xue-Yang, He, Na, Yin, Rui-Juan, Yang, Meng-Ke, Liu, Jie-Yu, Yu, Ri-Lei, Zhao, Chen-Yang, Jiang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875316/
https://www.ncbi.nlm.nih.gov/pubmed/35216314
http://dx.doi.org/10.3390/ijms23042199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875316/
https://www.ncbi.nlm.nih.gov/pubmed/35216314
http://dx.doi.org/10.3390/ijms23042199

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