PfMDR1 Transport Rates Assessed in Intact Isolated Plasmodium falciparum Digestive Vacuoles Reflect Functional Drug Resistance Relationship with pfmdr1 Mutations

Drug resistance often emerges from mutations in solute transporters. Single amino acid exchanges may alter functionality of transporters with ‘de novo’ ability to transport drugs away from their site of action. The PfMDR1 transporter (or P-glycoprotein 1) is located in the membrane of the digestive...

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Detalles Bibliográficos
Autores principales: Simon, Nina, Voigtländer, Cornelia, Kappes, Barbara, Rohrbach, Petra, Friedrich, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875337/
https://www.ncbi.nlm.nih.gov/pubmed/35215316
http://dx.doi.org/10.3390/ph15020202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875337/
https://www.ncbi.nlm.nih.gov/pubmed/35215316
http://dx.doi.org/10.3390/ph15020202

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