Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation

Specific inhibitors of mitochondrial 2-oxoglutarate dehydrogenase (OGDH) are administered to animals to model the downregulation of the enzyme as observed in neurodegenerative diseases. Comparison of the effects of succinyl phosphonate (SP, 0.02 mmol/kg) and its uncharged precursor, triethyl succiny...

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Detalles Bibliográficos
Autores principales: Artiukhov, Artem V., Graf, Anastasia V., Kazantsev, Alexey V., Boyko, Alexandra I., Aleshin, Vasily A., Ksenofontov, Alexander L., Bunik, Victoria I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875720/
https://www.ncbi.nlm.nih.gov/pubmed/35215295
http://dx.doi.org/10.3390/ph15020182

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8875720/
https://www.ncbi.nlm.nih.gov/pubmed/35215295
http://dx.doi.org/10.3390/ph15020182

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