Cargando…

A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids

Gefitinib is a tyrosine kinase inhibitor (TKI) that selectively inhibits the epidermal growth factor receptor (EGFR), hampering cell growth and proliferation. Due to its action, gefitinib has been used in the treatment of cancers that present abnormally increased expression of EGFR. However, side ef...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rodrigues, Daniela, Herpers, Bram, Ferreira, Sofia, Jo, Heeseung, Fisher, Ciarán, Coyle, Luke, Chung, Seung-Wook, Kleinjans, Jos C. S., Jennen, Danyel G. J., de Kok, Theo M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876167/ https://www.ncbi.nlm.nih.gov/pubmed/35216325 http://dx.doi.org/10.3390/ijms23042213

Ejemplares similares

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids
por: Rodrigues, Daniela, et al.
Publicado: (2022)

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids
por: Rodrigues, Daniela, et al.
Publicado: (2021)

Multi-omics HeCaToS dataset of repeated dose toxicity for cardiotoxic & hepatotoxic compounds
por: Verheijen, Marcha, et al.
Publicado: (2022)

DTNI: a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic compounds
por: Hendrickx, Diana M., et al.
Publicado: (2016)

A dynamic model of the intestinal epithelium integrates multiple sources of preclinical data and enables clinical translation of drug‐induced toxicity
por: Gall, Louis, et al.
Publicado: (2023)

Transcriptome analysis of long noncoding RNAs reveals their potential roles in anthracycline-induced cardiotoxicity
por: Nguyen, Nhan, et al.
Publicado: (2022)

New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis
por: Souza, Terezinha, et al.
Publicado: (2015)

Dose and Time Dependencies in Stress Pathway Responses during Chemical Exposure: Novel Insights from Gene Regulatory Networks
por: Souza, Terezinha M., et al.
Publicado: (2017)

MagiCMicroRna: a web implementation of AgiMicroRna using shiny
por: Coonen, Maarten LJ, et al.
Publicado: (2015)

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
por: Ruiz-Aracama, Ainhoa, et al.
Publicado: (2011)

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells
por: Jennen, Danyel, et al.
Publicado: (2011)

Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury
por: Souza, Terezinha, et al.
Publicado: (2018)

Translational Proteomics Analysis of Anthracycline-Induced Cardiotoxicity From Cardiac Microtissues to Human Heart Biopsies
por: Nguyen, Nhan, et al.
Publicado: (2021)

Transcriptomic Analysis in Human 3D Skin Model Injected with Resorbable Hyaluronic Acid Fillers Reveals Foreign Body Response
por: Jennen, Danyel G. J., et al.
Publicado: (2022)

Sex-Specific Associations between Particulate Matter Exposure and Gene Expression in Independent Discovery and Validation Cohorts of Middle-Aged Men and Women
por: Vrijens, Karen, et al.
Publicado: (2016)

Unraveling the mechanisms underlying drug-induced cholestatic liver injury: identifying key genes using machine learning techniques on human in vitro data sets
por: Jiang, Jian, et al.
Publicado: (2023)

Human kidney organoids model the tacrolimus nephrotoxicity and elucidate the role of autophagy
por: Kim, Jin Won, et al.
Publicado: (2021)

Cellular photo(geno)toxicity of gefitinib after biotransformation
por: El Ouardi, Meryem, et al.
Publicado: (2023)

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities
por: Wink, Steven, et al.
Publicado: (2016)

From multi-omics integration towards novel genomic interaction networks to identify key cancer cell line characteristics
por: Kuijpers, T. J. M., et al.
Publicado: (2021)

Evaluation of Adverse Effects of Resorbable Hyaluronic Acid Fillers: Determination of Macrophage Responses
por: De Jong, Wim H., et al.
Publicado: (2022)

SimRFlow: An R-based workflow for automated high-throughput PBPK simulation with the Simcyp(®) simulator
por: Khalidi, Hiba, et al.
Publicado: (2022)

Data on novel DNA methylation changes induced by valproic acid in human hepatocytes
por: Wolters, JarnoEJ, et al.
Publicado: (2017)

Newborn sex-specific transcriptome signatures and gestational exposure to fine particles: findings from the ENVIRONAGE birth cohort
por: Winckelmans, Ellen, et al.
Publicado: (2017)

Omics for prediction of environmental health effects: Blood leukocyte-based cross-omic profiling reliably predicts diseases associated with tobacco smoking
por: Georgiadis, Panagiotis, et al.
Publicado: (2016)

Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing
por: Bouwmeester, Manon C., et al.
Publicado: (2023)

DynOVis: a web tool to study dynamic perturbations for capturing dose-over-time effects in biological networks
por: Kuijpers, T. J. M., et al.
Publicado: (2019)

The Application of Brain Organoids in Assessing Neural Toxicity
por: Fan, Pan, et al.
Publicado: (2022)

Developing rat testicular organoid models for assessing the reproductive toxicity of antidepression drugs in vitro : Testicular organoids to assess antidepressants toxicity
por: Wu, Sixian, et al.
Publicado: (2022)

Inhibition of DNA-PK by gefitinib causes synergism between gefitinib and cisplatin in NSCLC
por: Pan, Chi, et al.
Publicado: (2020)

Comparison of statistical methods and the use of quality control samples for batch effect correction in human transcriptome data
por: Espín-Pérez, Almudena, et al.
Publicado: (2018)

Lung adenocarcinoma organoids harboring EGFR 19Del and L643V double mutations respond to osimertinib and gefitinib: A case report
por: Bie, Yanan, et al.
Publicado: (2021)

Chloroquine Enhances Gefitinib Cytotoxicity in Gefitinib-Resistant Nonsmall Cell Lung Cancer Cells
por: Tang, Mei-Chuan, et al.
Publicado: (2015)

Pilot study of radiofrequency hyperthermia in combination with gefitinib in gefitinib‐effective patients with advanced NSCLC
por: Qin, Yijia, et al.
Publicado: (2016)

Blood Transcriptome Response to Environmental Metal Exposure Reveals Potential Biological Processes Related to Alzheimer's Disease
por: Krauskopf, Julian, et al.
Publicado: (2020)

3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors
por: Badder, Luned M., et al.
Publicado: (2020)

Rhabdomyolysis Caused by Gefitinib Overdose
por: Obayashi, Shohei, et al.
Publicado: (2021)

Gefitinib: Dermatitis: case report
Publicado: (2022)

GENETIC POLYMORPHISMS OF THE ADENOSINE TRIPHOSPHATE-BINDING CASSETTE TRANSPORTERS(ABCG2, ABCB1) AND GEFITINIB TOXICITY
por: TAMURA, MARIKO, et al.
Publicado: (2012)

Clinical benefit of readministration of gefitinib for initial gefitinib-responders with non-small cell lung cancer
por: Yokouchi, Hiroshi, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_31nsv13mud0uc36je3onqpbmod