A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids

Gefitinib is a tyrosine kinase inhibitor (TKI) that selectively inhibits the epidermal growth factor receptor (EGFR), hampering cell growth and proliferation. Due to its action, gefitinib has been used in the treatment of cancers that present abnormally increased expression of EGFR. However, side ef...

Descripción completa

Detalles Bibliográficos
Autores principales: Rodrigues, Daniela, Herpers, Bram, Ferreira, Sofia, Jo, Heeseung, Fisher, Ciarán, Coyle, Luke, Chung, Seung-Wook, Kleinjans, Jos C. S., Jennen, Danyel G. J., de Kok, Theo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876167/
https://www.ncbi.nlm.nih.gov/pubmed/35216325
http://dx.doi.org/10.3390/ijms23042213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876167/
https://www.ncbi.nlm.nih.gov/pubmed/35216325
http://dx.doi.org/10.3390/ijms23042213

Ejemplares similares