Targeting KRAS Regulation with PolyPurine Reverse Hoogsteen Oligonucleotides

KRAS is a GTPase involved in the proliferation signaling of several growth factors. The KRAS gene is GC-rich, containing regions with known and putative G-quadruplex (G4) forming regions. Within the middle of the G-rich proximal promoter, stabilization of the physiologically active G4(mid) structure...

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Detalles Bibliográficos
Autores principales: Psaras, Alexandra Maria, Valiuska, Simonas, Noé, Véronique, Ciudad, Carlos J., Brooks, Tracy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876201/
https://www.ncbi.nlm.nih.gov/pubmed/35216221
http://dx.doi.org/10.3390/ijms23042097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876201/
https://www.ncbi.nlm.nih.gov/pubmed/35216221
http://dx.doi.org/10.3390/ijms23042097

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