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Targeting KRAS Regulation with PolyPurine Reverse Hoogsteen Oligonucleotides
KRAS is a GTPase involved in the proliferation signaling of several growth factors. The KRAS gene is GC-rich, containing regions with known and putative G-quadruplex (G4) forming regions. Within the middle of the G-rich proximal promoter, stabilization of the physiologically active G4(mid) structure...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876201/ https://www.ncbi.nlm.nih.gov/pubmed/35216221 http://dx.doi.org/10.3390/ijms23042097 |