Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis

Aristolochic acid (AA) is the causative nephrotoxic alkaloid in AA nephropathy, which results in a tubulointerstitial fibrosis. AA causes direct proximal tubule damage as well as an influx of macrophages, although the role of macrophages in pathogenesis is poorly understood. Here, we demonstrate tha...

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Detalles Bibliográficos
Autores principales: Sasaki, Kensuke, Terker, Andrew S., Tang, Jiaqi, Cao, Shirong, Arroyo, Juan Pablo, Niu, Aolei, Wang, Suwan, Fan, Xiaofeng, Zhang, Yahua, Bennett, Stephanie R., Zhang, Ming-zhi, Harris, Raymond C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876461/
https://www.ncbi.nlm.nih.gov/pubmed/35025763
http://dx.doi.org/10.1172/jci.insight.150723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876461/
https://www.ncbi.nlm.nih.gov/pubmed/35025763
http://dx.doi.org/10.1172/jci.insight.150723

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