Variants associated with Bedaquiline (BDQ) resistance identified in Rv0678 and efflux pump genes in Mycobacterium tuberculosis isolates from BDQ naïve TB patients in Pakistan

BACKGROUND: Mutations in the Rv0678, pepQ and atpE genes of Mycobacterium tuberculosis (MTB) have been reported to be associated with reduced antimycobacterial susceptibility to bedaquiline (BDQ). Resistance conferring mutations in treatment naïve MTB strains is likely to have implications for BDQ b...

Descripción completa

Detalles Bibliográficos
Autores principales: Saeed, Dania Khalid, Shakoor, Sadia, Razzak, Safina Abdul, Hasan, Zahra, Sabzwari, Saba Faraz, Azizullah, Zahida, Kanji, Akbar, Nasir, Asghar, Shafiq, Samreen, Ghanchi, Najia Karim, Hasan, Rumina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876534/
https://www.ncbi.nlm.nih.gov/pubmed/35209842
http://dx.doi.org/10.1186/s12866-022-02475-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876534/
https://www.ncbi.nlm.nih.gov/pubmed/35209842
http://dx.doi.org/10.1186/s12866-022-02475-4

Ejemplares similares