Phosphomimetic Tyrosine Mutations in Spa47 Inhibit Type Three Secretion ATPase Activity and Shigella Virulence Phenotype

Shigella is a highly infectious human pathogen responsible for 269 million infections and 200,000 deaths per year. Shigella virulence is absolutely reliant on the injection of effector proteins into the host cell cytoplasm via its type three secretion system (T3SS). The protein Spa47 is a T3SS ATPas...

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Detalles Bibliográficos
Autores principales: Hardy, Koleton D., Dickenson, Nicholas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876561/
https://www.ncbi.nlm.nih.gov/pubmed/35215145
http://dx.doi.org/10.3390/pathogens11020202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876561/
https://www.ncbi.nlm.nih.gov/pubmed/35215145
http://dx.doi.org/10.3390/pathogens11020202

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