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Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1

β-Secretase 1 (β-site amyloid precursor protein [APP]-cleaving enzyme 1, BACE1) plays a crucial role in the amyloidogenesis of Alzheimer’s disease (AD). BACE1 was also discovered to act like an auxiliary subunit to modulate neuronal KCNQ2/3 channels independently of its proteolytic function. BACE1 i...

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Detalles Bibliográficos
Autor principal: Dai, Gucan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876601/
https://www.ncbi.nlm.nih.gov/pubmed/35201266
http://dx.doi.org/10.1085/jgp.202112888