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Neuronal KCNQ2/3 channels are recruited to lipid raft microdomains by palmitoylation of BACE1
β-Secretase 1 (β-site amyloid precursor protein [APP]-cleaving enzyme 1, BACE1) plays a crucial role in the amyloidogenesis of Alzheimer’s disease (AD). BACE1 was also discovered to act like an auxiliary subunit to modulate neuronal KCNQ2/3 channels independently of its proteolytic function. BACE1 i...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Rockefeller University Press
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876601/ https://www.ncbi.nlm.nih.gov/pubmed/35201266 http://dx.doi.org/10.1085/jgp.202112888 |