Practical Synthesis of Phosphinic Dipeptides by Tandem Esterification of Aminophosphinic and Acrylic Acids under Silylating Conditions

In this report, a synthetic protocol for the preparation of phosphinic dipeptides of type 5 is presented. These compounds serve as valuable building blocks for the development of highly potent phosphinopeptidic inhibitors of medicinally relevant Zn-metalloproteases and aspartyl proteases. The propos...

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Detalles Bibliográficos
Autores principales: Kokkala, Paraskevi, Voreakos, Kostas, Lelis, Angelos, Patiniotis, Konstantinos, Skoulikas, Nikolaos, Devel, Laurent, Ziotopoulou, Angeliki, Kaloumenou, Eleni, Georgiadis, Dimitris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876710/
https://www.ncbi.nlm.nih.gov/pubmed/35209031
http://dx.doi.org/10.3390/molecules27041242

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876710/
https://www.ncbi.nlm.nih.gov/pubmed/35209031
http://dx.doi.org/10.3390/molecules27041242

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