PERK activation by SB202190 ameliorates amyloidogenesis via the TFEB-induced autophagy-lysosomal pathway

The protein kinase R (PKR)-like endoplasmic reticulum (ER) kinase (PERK), a key ER stress sensor of the unfolded protein response (UPR), can confer beneficial effects by facilitating the removal of cytosolic aggregates through the autophagy-lysosome pathway (ALP). In neurodegenerative diseases, the...

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Detalles Bibliográficos
Autores principales: Do, Mihyang, Park, Jeongmin, Chen, Yubing, Rah, So-Young, Nghiem, Thu-Hang Thi, Gong, Jeong Heon, Ju, Seong-A, Kim, Byung-Sam, Yu, Rina, Park, Jeong Woo, Ryter, Stefan W., Surh, Young-Joon, Kim, Uh-Hyun, Joe, Yeonsoo, Chung, Hun Taeg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876914/
https://www.ncbi.nlm.nih.gov/pubmed/35166693
http://dx.doi.org/10.18632/aging.203899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876914/
https://www.ncbi.nlm.nih.gov/pubmed/35166693
http://dx.doi.org/10.18632/aging.203899

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