TDP-43 Proteinopathy Causes Broad Metabolic Alterations including TCA Cycle Intermediates and Dopamine Levels in Drosophila Models of ALS

Amyotrophic lateral sclerosis (ALS) is a fatal, complex neurodegenerative disorder that causes selective degeneration of motor neurons. ALS patients exhibit symptoms consistent with altered cellular energetics such as hypermetabolism, weight loss, dyslipidemia, insulin resistance, and altered glucos...

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Detalles Bibliográficos
Autores principales: Loganathan, Suvithanandhini, Wilson, Bryce A., Carey, Sara B., Manzo, Ernesto, Joardar, Archi, Ugur, Berrak, Zarnescu, Daniela C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876928/
https://www.ncbi.nlm.nih.gov/pubmed/35208176
http://dx.doi.org/10.3390/metabo12020101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876928/
https://www.ncbi.nlm.nih.gov/pubmed/35208176
http://dx.doi.org/10.3390/metabo12020101

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