New Insights on Rotenone Resistance of Complex I Induced by the m.11778G>A/MT-ND4 Mutation Associated with Leber’s Hereditary Optic Neuropathy

The finding that the most common mitochondrial DNA mutation m.11778G>A/MT-ND4 (p.R340H) associated with Leber’s hereditary optic neuropathy (LHON) induces rotenone resistance has produced a long-standing debate, because it contrasts structural evidence showing that the ND4 subunit is far away fro...

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Detalles Bibliográficos
Autores principales: Musiani, Francesco, Rigobello, Laura, Iommarini, Luisa, Carelli, Valerio, Degli Esposti, Mauro, Ghelli, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876992/
https://www.ncbi.nlm.nih.gov/pubmed/35209128
http://dx.doi.org/10.3390/molecules27041341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8876992/
https://www.ncbi.nlm.nih.gov/pubmed/35209128
http://dx.doi.org/10.3390/molecules27041341

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