Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors

The sterol biosynthesis pathway of Leishmania spp. is used as a pharmacological target; however, available information about the mechanisms of the regulation and remodeling of sterol-related genes is scarce. The present study investigated compensatory mechanisms of the sterol biosynthesis pathway us...

Descripción completa

Detalles Bibliográficos
Autores principales: Fujii, Thais Tenorio Soares, Gomes, Pollyanna Stephanie, do Monte-Neto, Rubens Lima, de Oliveira Gomes, Daniel Claudio, Ouellette, Marc, Torres-Santos, Eduardo Caio, Andrade-Neto, Valter Viana, de Matos Guedes, Herbert Leonel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877030/
https://www.ncbi.nlm.nih.gov/pubmed/35208853
http://dx.doi.org/10.3390/microorganisms10020398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877030/
https://www.ncbi.nlm.nih.gov/pubmed/35208853
http://dx.doi.org/10.3390/microorganisms10020398

Ejemplares similares