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Simvastatin Resistance of Leishmania amazonensis Induces Sterol Remodeling and Cross-Resistance to Sterol Pathway and Serine Protease Inhibitors

The sterol biosynthesis pathway of Leishmania spp. is used as a pharmacological target; however, available information about the mechanisms of the regulation and remodeling of sterol-related genes is scarce. The present study investigated compensatory mechanisms of the sterol biosynthesis pathway us...

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Detalles Bibliográficos
Autores principales:	Fujii, Thais Tenorio Soares, Gomes, Pollyanna Stephanie, do Monte-Neto, Rubens Lima, de Oliveira Gomes, Daniel Claudio, Ouellette, Marc, Torres-Santos, Eduardo Caio, Andrade-Neto, Valter Viana, de Matos Guedes, Herbert Leonel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877030/ https://www.ncbi.nlm.nih.gov/pubmed/35208853 http://dx.doi.org/10.3390/microorganisms10020398

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