Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models

Boswellia serrata, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metaboli...

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Autores principales: Suther, Cassandra, Daddi, Lauren, Bokoliya, Suresh, Panier, Hunter, Liu, Zhongmao, Lin, Qingqi, Han, Yanhui, Chen, Kun, Moore, Matthew D., Zhou, Yanjiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877038/
https://www.ncbi.nlm.nih.gov/pubmed/35215464
http://dx.doi.org/10.3390/nu14040814
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author Suther, Cassandra
Daddi, Lauren
Bokoliya, Suresh
Panier, Hunter
Liu, Zhongmao
Lin, Qingqi
Han, Yanhui
Chen, Kun
Moore, Matthew D.
Zhou, Yanjiao
author_facet Suther, Cassandra
Daddi, Lauren
Bokoliya, Suresh
Panier, Hunter
Liu, Zhongmao
Lin, Qingqi
Han, Yanhui
Chen, Kun
Moore, Matthew D.
Zhou, Yanjiao
author_sort Suther, Cassandra
collection PubMed
description Boswellia serrata, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metabolites, is not known. In this study, we observe the effect of this isolated active ingredient orally on both male and female mice. Gut microbiota and blood metabolites were determined at the beginning and end of a 14-day consumption period. AKBA significantly decreased gut bacterial richness in male mice, and had no effect on female mice. Akkermansia muciniphila, associated with weight loss and anti-inflammation, was found to be significantly increased in both male and female mice, along with an increase in Bifidobacterium in female mice. Akkermansia muciniphila and Bifidobacterium were plated on media containing varying levels of AKBA (0%, 0.001%, 0.01%, and 0.1%). All concentrations of AKBA completely inhibited growth of Akkermansia muciniphila but had no effect on Bifidobacterium. Several blood metabolites differed with AKBA between both males and females. These results show the potential benefits of dietary Boswellia serrata on the modulation of gut microbiome composition, along with differences between sexes.
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spelling pubmed-88770382022-02-26 Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models Suther, Cassandra Daddi, Lauren Bokoliya, Suresh Panier, Hunter Liu, Zhongmao Lin, Qingqi Han, Yanhui Chen, Kun Moore, Matthew D. Zhou, Yanjiao Nutrients Article Boswellia serrata, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metabolites, is not known. In this study, we observe the effect of this isolated active ingredient orally on both male and female mice. Gut microbiota and blood metabolites were determined at the beginning and end of a 14-day consumption period. AKBA significantly decreased gut bacterial richness in male mice, and had no effect on female mice. Akkermansia muciniphila, associated with weight loss and anti-inflammation, was found to be significantly increased in both male and female mice, along with an increase in Bifidobacterium in female mice. Akkermansia muciniphila and Bifidobacterium were plated on media containing varying levels of AKBA (0%, 0.001%, 0.01%, and 0.1%). All concentrations of AKBA completely inhibited growth of Akkermansia muciniphila but had no effect on Bifidobacterium. Several blood metabolites differed with AKBA between both males and females. These results show the potential benefits of dietary Boswellia serrata on the modulation of gut microbiome composition, along with differences between sexes. MDPI 2022-02-15 /pmc/articles/PMC8877038/ /pubmed/35215464 http://dx.doi.org/10.3390/nu14040814 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Suther, Cassandra
Daddi, Lauren
Bokoliya, Suresh
Panier, Hunter
Liu, Zhongmao
Lin, Qingqi
Han, Yanhui
Chen, Kun
Moore, Matthew D.
Zhou, Yanjiao
Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models
title Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models
title_full Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models
title_fullStr Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models
title_full_unstemmed Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models
title_short Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models
title_sort dietary boswellia serrata acid alters the gut microbiome and blood metabolites in experimental models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877038/
https://www.ncbi.nlm.nih.gov/pubmed/35215464
http://dx.doi.org/10.3390/nu14040814
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