Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models
Boswellia serrata, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metaboli...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877038/ https://www.ncbi.nlm.nih.gov/pubmed/35215464 http://dx.doi.org/10.3390/nu14040814 |
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author | Suther, Cassandra Daddi, Lauren Bokoliya, Suresh Panier, Hunter Liu, Zhongmao Lin, Qingqi Han, Yanhui Chen, Kun Moore, Matthew D. Zhou, Yanjiao |
author_facet | Suther, Cassandra Daddi, Lauren Bokoliya, Suresh Panier, Hunter Liu, Zhongmao Lin, Qingqi Han, Yanhui Chen, Kun Moore, Matthew D. Zhou, Yanjiao |
author_sort | Suther, Cassandra |
collection | PubMed |
description | Boswellia serrata, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metabolites, is not known. In this study, we observe the effect of this isolated active ingredient orally on both male and female mice. Gut microbiota and blood metabolites were determined at the beginning and end of a 14-day consumption period. AKBA significantly decreased gut bacterial richness in male mice, and had no effect on female mice. Akkermansia muciniphila, associated with weight loss and anti-inflammation, was found to be significantly increased in both male and female mice, along with an increase in Bifidobacterium in female mice. Akkermansia muciniphila and Bifidobacterium were plated on media containing varying levels of AKBA (0%, 0.001%, 0.01%, and 0.1%). All concentrations of AKBA completely inhibited growth of Akkermansia muciniphila but had no effect on Bifidobacterium. Several blood metabolites differed with AKBA between both males and females. These results show the potential benefits of dietary Boswellia serrata on the modulation of gut microbiome composition, along with differences between sexes. |
format | Online Article Text |
id | pubmed-8877038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88770382022-02-26 Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models Suther, Cassandra Daddi, Lauren Bokoliya, Suresh Panier, Hunter Liu, Zhongmao Lin, Qingqi Han, Yanhui Chen, Kun Moore, Matthew D. Zhou, Yanjiao Nutrients Article Boswellia serrata, commonly known as frankincense, has been used for centuries as a natural anti-inflammatory and anti-microbial remedy for many illnesses. However, the effect of the bioactive ingredient of it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both the gut microbiome and blood metabolites, is not known. In this study, we observe the effect of this isolated active ingredient orally on both male and female mice. Gut microbiota and blood metabolites were determined at the beginning and end of a 14-day consumption period. AKBA significantly decreased gut bacterial richness in male mice, and had no effect on female mice. Akkermansia muciniphila, associated with weight loss and anti-inflammation, was found to be significantly increased in both male and female mice, along with an increase in Bifidobacterium in female mice. Akkermansia muciniphila and Bifidobacterium were plated on media containing varying levels of AKBA (0%, 0.001%, 0.01%, and 0.1%). All concentrations of AKBA completely inhibited growth of Akkermansia muciniphila but had no effect on Bifidobacterium. Several blood metabolites differed with AKBA between both males and females. These results show the potential benefits of dietary Boswellia serrata on the modulation of gut microbiome composition, along with differences between sexes. MDPI 2022-02-15 /pmc/articles/PMC8877038/ /pubmed/35215464 http://dx.doi.org/10.3390/nu14040814 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Suther, Cassandra Daddi, Lauren Bokoliya, Suresh Panier, Hunter Liu, Zhongmao Lin, Qingqi Han, Yanhui Chen, Kun Moore, Matthew D. Zhou, Yanjiao Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models |
title | Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models |
title_full | Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models |
title_fullStr | Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models |
title_full_unstemmed | Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models |
title_short | Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models |
title_sort | dietary boswellia serrata acid alters the gut microbiome and blood metabolites in experimental models |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877038/ https://www.ncbi.nlm.nih.gov/pubmed/35215464 http://dx.doi.org/10.3390/nu14040814 |
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