Employing CRISPR-Cas9 to Generate CD133 Synthetic Lethal Melanoma Stem Cells

Malignant melanoma is a lethal skin cancer containing melanoma-initiating cells (MIC) implicated in tumorigenesis, invasion, and drug resistance, and is characterized by the elevated expression of stem cell markers, including CD133. The siRNA knockdown of CD133 enhances apoptosis induced by the MEK...

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Detalles Bibliográficos
Autores principales: Simbulan-Rosenthal, Cynthia M., Haribabu, Yogameenakshi, Vakili, Sahar, Kuo, Li-Wei, Clark, Havens, Dougherty, Ryan, Alobaidi, Ryyan, Carney, Bonnie, Sykora, Peter, Rosenthal, Dean S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877091/
https://www.ncbi.nlm.nih.gov/pubmed/35216449
http://dx.doi.org/10.3390/ijms23042333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877091/
https://www.ncbi.nlm.nih.gov/pubmed/35216449
http://dx.doi.org/10.3390/ijms23042333

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