Cargando…

Design and Synthesis of Arylpiperazine Serotonergic/Dopaminergic Ligands with Neuroprotective Properties

Long-chain arylpiperazine scaffold is a versatile template to design central nervous system (CNS) drugs that target serotonin and dopamine receptors. Here we describe the synthesis and biological evaluation of ten new arylpiperazine derivatives designed to obtain an affinity profile at serotonin 5-H...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mastromarino, Margherita, Niso, Mauro, Abate, Carmen, Proschak, Ewgenij, Dubiel, Mariam, Stark, Holger, Castro, Marián, Lacivita, Enza, Leopoldo, Marcello
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877291/ https://www.ncbi.nlm.nih.gov/pubmed/35209087 http://dx.doi.org/10.3390/molecules27041297

Ejemplares similares

σ(2) Receptor and Its Role in Cancer with Focus on a MultiTarget Directed Ligand (MTDL) Approach
por: Abatematteo, Francesca Serena, et al.
Publicado: (2021)

The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT(7) receptor binding and cAMP signaling
por: Atanes, Patricio, et al.
Publicado: (2013)

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1–42)-Induced Neuroinflammation in Mouse Models of Alzheimer’s Disease
por: Trojan, Ewa, et al.
Publicado: (2021)

PocketPicker: analysis of ligand binding-sites with shape descriptors
por: Weisel, Martin, et al.
Publicado: (2007)

Low Basicity as a Characteristic for Atypical Ligands of Serotonin Receptor 5-HT2
por: Podlewska, Sabina, et al.
Publicado: (2021)

Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology
por: Tylek, Kinga, et al.
Publicado: (2021)

Multi-Target Directed Ligands (MTDLs) Binding the σ(1) Receptor as Promising Therapeutics: State of the Art and Perspectives
por: Abatematteo, Francesca Serena, et al.
Publicado: (2021)

Behavioral, Anti-Inflammatory, and Neuroprotective Effects of a Novel FPR2 Agonist in Two Mouse Models of Autism
por: Cristiano, Claudia, et al.
Publicado: (2022)

In silico polypharmacology: retrospective recognition vs. rational design
por: Proschak, Ewgenij
Publicado: (2014)

5-HT(7) Receptors Regulate Excitatory-Inhibitory Balance in Mouse Spinal Cord Dorsal Horn
por: Comitato, Antonella, et al.
Publicado: (2022)

Dopaminergic, serotonergic, and noradrenergic deficits in Parkinson disease
por: Buddhala, Chandana, et al.
Publicado: (2015)

Serotonergic and dopaminergic control of impulsivity in gambling disorder
por: Kaasinen, Valtteri, et al.
Publicado: (2023)

Mitochondrial Membranes of Human SH-SY5Y Neuroblastoma Cells Express Serotonin 5-HT(7) Receptor
por: Tempio, Alessandra, et al.
Publicado: (2020)

Reversible Small Molecule Inhibitors of MAO A and MAO B with Anilide Motifs
por: Hagenow, Jens, et al.
Publicado: (2020)

Serotonin 5‐HT7 receptors require cyclin‐dependent kinase 5 to rescue hippocampal synaptic plasticity in a mouse model of Fragile X Syndrome
por: Costa, Lara, et al.
Publicado: (2021)

Prior Activation of 5-HT7 Receptors Modulates the Conditioned Place Preference With Methylphenidate
por: Carbone, Cristiana, et al.
Publicado: (2019)

Novel agonists for serotonin 5-HT(7) receptors reverse metabotropic glutamate receptor-mediated long-term depression in the hippocampus of wild-type and Fmr1 KO mice, a model of Fragile X Syndrome
por: Costa, Lara, et al.
Publicado: (2015)

The Formyl Peptide Receptor 2 as a Target for Promotion of Resolution of Inflammation
por: Trojan, Ewa, et al.
Publicado: (2023)

Human fear reconsolidation and allelic differences in serotonergic and dopaminergic genes
por: Agren, T, et al.
Publicado: (2012)

Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems
por: Cordeiro, L.M.S., et al.
Publicado: (2017)

Differential contributions of serotonergic and dopaminergic functional connectivity to the phenomenology of LSD
por: Lawn, Timothy, et al.
Publicado: (2022)

The brain-penetrant 5-HT(7) receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain
por: Santello, Mirko, et al.
Publicado: (2017)

Comprehensive exploration of the genetic contribution of the dopaminergic and serotonergic pathways to psychiatric disorders
por: Cabana-Domínguez, Judit, et al.
Publicado: (2022)

DOGS: Reaction-Driven de novo Design of Bioactive Compounds
por: Hartenfeller, Markus, et al.
Publicado: (2012)

Photocatalysis and Kinetic Resolution by Lithiation to Give Enantioenriched 2-Arylpiperazines
por: Das, Anjan, et al.
Publicado: (2023)

Solvates of New Arylpiperazine Salicylamide Derivative-a Multi-Technique Approach to the Description of 5 HTR Ligand Structure and Interactions
por: Pindelska, Edyta, et al.
Publicado: (2021)

Design of dual ligands using excessive pharmacophore query alignment
por: Moser, Daniel, et al.
Publicado: (2012)

Fragment-based identification of multi-target ligands by self-organizing map alignment
por: Achenbach, Janosch, et al.
Publicado: (2012)

Imbalanced Dopaminergic Transmission Mediated by Serotonergic Neurons in L-DOPA-Induced Dyskinesia
por: Navailles, Sylvia, et al.
Publicado: (2012)

Differential regulation of amphetamine-induced serotonergic and dopaminergic efflux by syntaxin 1A
por: Montgomery, Therese, et al.
Publicado: (2011)

Serotonergic, Dopaminergic, and Noradrenergic Modulation of Erotic Stimulus Processing in the Male Human Brain
por: Graf, Heiko, et al.
Publicado: (2019)

The pleiotropic contribution of genes in dopaminergic and serotonergic pathways to addiction and related behavioral traits
por: Antón-Galindo, Ester, et al.
Publicado: (2023)

SBE13, a newly identified inhibitor of inactive polo-like kinase 1
por: Keppner, Sarah, et al.
Publicado: (2010)

Multi-Target Approaches in Metabolic Syndrome
por: Lillich, Felix F., et al.
Publicado: (2021)

Synthesis and Antitumor Activity of Novel Arylpiperazine Derivatives Containing the Saccharin Moiety
por: Chen, Hong, et al.
Publicado: (2017)

Design, synthesis, and biological evaluation of N-arylpiperazine derivatives as interferon inducers
por: Chu, Yeonjeong, et al.
Publicado: (2020)

Kernel learning for ligand-based virtual screening: discovery of a new PPARγ agonist
por: Rupp, Matthias, et al.
Publicado: (2010)

Distribution of serotonergic and dopaminergic nerve fibers in the salivary gland complex of the cockroach Periplaneta americana
por: Baumann, Otto, et al.
Publicado: (2002)

The role of dopaminergic and serotonergic systems in neurodevelopmental disorders: a focus on epilepsy and seizure susceptibility
por: Tripathi, Prem Prakash, et al.
Publicado: (2015)

Early Degeneration of Both Dopaminergic and Serotonergic Axons – A Common Mechanism in Parkinson’s Disease
por: Grosch, Janina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tb07vb99c5s3v544bs408qj70n