Utilization of Polymeric Micelles as a Lucrative Platform for Efficient Brain Deposition of Olanzapine as an Antischizophrenic Drug via Intranasal Delivery

Schizophrenia is a mental disorder characterized by alterations in cognition, behavior and emotions. Oral olanzapine (OZ) administration is extensively metabolized (~up to 40% of the administrated dose). In addition, OZ is a P-glycoproteins substrate that impairs the blood–brain barrier (BBB) permea...

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Detalles Bibliográficos
Autores principales: Abo El-Enin, Hadel A., Ahmed, Marwa F., Naguib, Ibrahim A., El-Far, Shaymaa W., Ghoneim, Mohammed M., Alsalahat, Izzeddin, Abdel-Bar, Hend Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877317/
https://www.ncbi.nlm.nih.gov/pubmed/35215361
http://dx.doi.org/10.3390/ph15020249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877317/
https://www.ncbi.nlm.nih.gov/pubmed/35215361
http://dx.doi.org/10.3390/ph15020249

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