NGF/TRKA Promotes ADAM17-Dependent Cleavage of P75 in Ovarian Cells: Elucidating a Pro-Tumoral Mechanism

Nerve growth factor (NGF) and its high-affinity receptor TRKA are overexpressed in epithelial ovarian cancer (EOC) displaying a crucial role in the disease progression. Otherwise, NGF interacts with its low-affinity receptor P75, activating pro-apoptotic pathways. In neurons, P75 could be cleaved by...

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Detalles Bibliográficos
Autores principales: Garrido, Maritza P., Vallejos, Christopher, Girardi, Silvanna, Gabler, Fernando, Selman, Alberto, López, Fernanda, Vega, Margarita, Romero, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877415/
https://www.ncbi.nlm.nih.gov/pubmed/35216240
http://dx.doi.org/10.3390/ijms23042124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877415/
https://www.ncbi.nlm.nih.gov/pubmed/35216240
http://dx.doi.org/10.3390/ijms23042124

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