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Impact of α‐synuclein spreading on the nigrostriatal dopaminergic pathway depends on the onset of the pathology

Misfolded α‐synuclein spreads along anatomically connected areas through the brain, prompting progressive neurodegeneration of the nigrostriatal pathway in Parkinson's disease. To investigate the impact of early stage seeding and spreading of misfolded α‐synuclein along with the nigrostriatal p...

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Detalles Bibliográficos
Autores principales: Sun, Fanfan, Salinas, Armando G., Filser, Severin, Blumenstock, Sonja, Medina‐Luque, Jose, Herms, Jochen, Sgobio, Carmelo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877754/
https://www.ncbi.nlm.nih.gov/pubmed/34806235
http://dx.doi.org/10.1111/bpa.13036