Cargando…

Identification and Validation of Ikaros (IKZF1) as a Cancer Driver Gene for Marek’s Disease Virus-Induced Lymphomas

Marek’s disease virus (MDV) is the causative agent for Marek’s disease (MD), which is characterized by T-cell lymphomas in chickens. While the viral Meq oncogene is necessary for transformation, it is insufficient, as not every bird infected with virulent MDV goes on to develop a gross tumor. Thus,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Steep, Alec, Hildebrandt, Evin, Xu, Hongen, Hearn, Cari, Frishman, Dmitrij, Niikura, Masahiro, Dunn, John R., Kim, Taejoong, Conrad, Steven J., Muir, William M., Cheng, Hans H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877892/ https://www.ncbi.nlm.nih.gov/pubmed/35208856 http://dx.doi.org/10.3390/microorganisms10020401

Ejemplares similares

The immune cell landscape and response of Marek’s disease resistant and susceptible chickens infected with Marek’s disease virus
por: Warren, Wesley C., et al.
Publicado: (2023)

Phenotypic Characterization of Recombinant Marek’s Disease Virus in Live Birds Validates Polymorphisms Associated with Virulence
por: Kim, Taejoong, et al.
Publicado: (2023)

Impaired tissue homing by the Ikzf3(N159S) variant is mediated by interfering with Ikaros function
por: Chang, Jingjie, et al.
Publicado: (2023)

Contribution of the TCRβ Repertoire to Marek’s Disease Genetic Resistance in the Chicken
por: Hearn, Cari J., et al.
Publicado: (2023)

An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes
por: Swafford, Austin D.-E., et al.
Publicado: (2011)

B cells do not play a role in vaccine-mediated immunity against Marek’s disease
por: Heidari, Mohammad, et al.
Publicado: (2021)

Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency
por: Eskandarian, Zoya, et al.
Publicado: (2019)

Corrigendum: Assessing the Functional Relevance of Variants in the IKAROS Family Zinc Finger Protein 1 (IKZF1) in a Cohort of Patients With Primary Immunodeficiency
por: Eskandarian, Zoya, et al.
Publicado: (2019)

Lenalidomide induces degradation of IKZF1 and IKZF3
por: Krönke, Jan, et al.
Publicado: (2014)

The Ikaros family of zinc-finger proteins
por: Fan, Yingzhi, et al.
Publicado: (2016)

Baicalein Inhibits Proliferation of Myeloma U266 Cells by Downregulating IKZF1 and IKZF3
por: Liu, Xiao-Ping, et al.
Publicado: (2018)

Ikaros as a downstream mediator of BCR blockade therapy in B-cell non-Hodgkin lymphoma
por: Ribeiro, Marcelo Lima, et al.
Publicado: (2022)

Regulatory Phosphorylation of Ikaros by Bruton's Tyrosine Kinase
por: Ma, Hong, et al.
Publicado: (2013)

Sumoylation Inhibits the Growth Suppressive Properties of Ikaros
por: Apostolov, Apostol, et al.
Publicado: (2016)

High Expression of IKZF2 in Malignant T Cells Promotes Disease Progression in Cutaneous T Cell Lymphoma
por: XU, Bufang, et al.
Publicado: (2021)

An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities
por: Perotti, Elizabeth A., et al.
Publicado: (2015)

Correction: Sumoylation Inhibits the Growth Suppressive Properties of Ikaros
Publicado: (2016)

Ikaros Proteins in Tumor: Current Perspectives and New Developments
por: Xia, Ruolan, et al.
Publicado: (2021)

Genetic Mapping and Allelic Loss Analysis in Mouse Thymic Lymphomas of Helios and Aiolos Belonging to the Ikaros Gene Family
por: Xu, Hongbin, et al.
Publicado: (2001)

Development of Label-Free Impedimetric Immunosensors for IKZF1 and IKZF3 Femtomolar Detection for Monitoring Multiple Myeloma Patients Treated with Lenalidomide
por: Abdulkarim, Haya, et al.
Publicado: (2020)

Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice
por: Nichogiannopoulou, Aliki, et al.
Publicado: (1999)

Differential regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros
por: Schjerven, Hilde, et al.
Publicado: (2013)

Prognostic impact of Ikaros expression in lenalidomide-treated multiple myeloma
por: Krönke, Jan, et al.
Publicado: (2017)

Ikaros-Associated Diseases: From Mice to Humans and Back Again
por: Boast, Brigette, et al.
Publicado: (2021)

Ikaros Regulates microRNA Networks in Acute Lymphoblastic Leukemia
por: Kogut, Sophie, et al.
Publicado: (2022)

Deletion of the Viral Thymidine Kinase in a Meq-Deleted Recombinant Marek’s Disease Virus Reduces Lymphoid Atrophy but Is Less Protective
por: Conrad, Steven J., et al.
Publicado: (2021)

Applying negative rule mining to improve genome annotation
por: Artamonova, Irena I, et al.
Publicado: (2007)

Molecular epidemiology of Marek’s disease virus in central Pennsylvania, USA
por: Bell, Andrew S, et al.
Publicado: (2019)

Assignment of isochores for all completely sequenced vertebrate genomes using a consensus
por: Schmidt, Thorsten, et al.
Publicado: (2008)

Fold Designability, Distribution, and Disease
por: Wong, Philip, et al.
Publicado: (2006)

PROMPT: a protein mapping and comparison tool
por: Schmidt, Thorsten, et al.
Publicado: (2006)

Prediction of protein interaction types based on sequence and network features
por: Goebels, Florian, et al.
Publicado: (2013)

Analysis of Micro-Rearrangements in 25 Eukaryotic Species Pairs by SyntenyMapper
por: Kaufmann, Stefanie, et al.
Publicado: (2014)

Melting temperature highlights functionally important RNA structure and sequence elements in yeast mRNA coding regions
por: Qi, Fei, et al.
Publicado: (2017)

Improved sequence-based prediction of interaction sites in α-helical transmembrane proteins by deep learning
por: Sun, Jianfeng, et al.
Publicado: (2021)

Trans-Ancestral Fine-Mapping and Epigenetic Annotation as Tools to Delineate Functionally Relevant Risk Alleles at IKZF1 and IKZF3 in Systemic Lupus Erythematosus
por: Vyse, Timothy J., et al.
Publicado: (2020)

Critical Role of the Virus-Encoded MicroRNA-155 Ortholog in the Induction of Marek's Disease Lymphomas
por: Zhao, Yuguang, et al.
Publicado: (2011)

Ikaros controls isotype selection during immunoglobulin class switch recombination
por: Sellars, MacLean, et al.
Publicado: (2009)

Murine Pancreatic Adenocarcinoma Reduces Ikaros Expression and Disrupts T Cell Homeostasis
por: Nelson, Nadine, et al.
Publicado: (2015)

The Role of the Ikaros Family of Transcription Factors in Regulatory T cell Development and Function
por: Seng, Amara, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_23klm08upptp3ki76db6u6oi3g