Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings

The uremic toxin indoxyl sulfate (IS), elevated in chronic kidney disease (CKD), is known to contribute towards progressive cardiovascular disease. IS activates the aryl hydrocarbon receptor (AhR) mediating oxidative stress and endothelial dysfunction via activation of the CYP1A1 pathway. The presen...

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Detalles Bibliográficos
Autores principales: Nguyen, Cindy, Edgley, Amanda J., Kelly, Darren J., Kompa, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878015/
https://www.ncbi.nlm.nih.gov/pubmed/35202128
http://dx.doi.org/10.3390/toxins14020100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878015/
https://www.ncbi.nlm.nih.gov/pubmed/35202128
http://dx.doi.org/10.3390/toxins14020100

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