VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor

HDAC inhibitors (HDACi) represent promising anti-cancer treatments, as the acetylation of histone and non-histone proteins is often dysregulated in cancer and contributes to cancer onset and progression. HDACi have been also reported to increase the cytotoxicity of DNA-damaging agents, such as radia...

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Detalles Bibliográficos
Autores principales: Romeo, Maria Anele, Gilardini Montani, Maria Saveria, Benedetti, Rossella, Arena, Andrea, D’Orazi, Gabriella, Cirone, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878079/
https://www.ncbi.nlm.nih.gov/pubmed/35216385
http://dx.doi.org/10.3390/ijms23042268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878079/
https://www.ncbi.nlm.nih.gov/pubmed/35216385
http://dx.doi.org/10.3390/ijms23042268

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