Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and MMV084978) selects for mutations in PfAcAS. Metabolic profiling of com...

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Detalles Bibliográficos
Autores principales: Summers, Robert L., Pasaje, Charisse Flerida A., Pisco, Joao P., Striepen, Josefine, Luth, Madeline R., Kumpornsin, Krittikorn, Carpenter, Emma F., Munro, Justin T., Lin, De, Plater, Andrew, Punekar, Avinash S., Shepherd, Andrew M., Shepherd, Sharon M., Vanaerschot, Manu, Murithi, James M., Rubiano, Kelly, Akidil, Aslı, Ottilie, Sabine, Mittal, Nimisha, Dilmore, A. Hazel, Won, Madalyn, Mandt, Rebecca E.K., McGowen, Kerry, Owen, Edward, Walpole, Chris, Llinás, Manuel, Lee, Marcus C.S., Winzeler, Elizabeth A., Fidock, David A., Gilbert, Ian H., Wirth, Dyann F., Niles, Jacquin C., Baragaña, Beatriz, Lukens, Amanda K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878317/
https://www.ncbi.nlm.nih.gov/pubmed/34348113
http://dx.doi.org/10.1016/j.chembiol.2021.07.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878317/
https://www.ncbi.nlm.nih.gov/pubmed/34348113
http://dx.doi.org/10.1016/j.chembiol.2021.07.010

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