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Antileishmanial Efficacy of the Calpain Inhibitor MDL28170 in Combination with Amphotericin B

The necessity of drug combinations to treat leishmaniasis came to the surface mainly because of the toxicity of current treatments and the emergence of resistant strains. The calpain inhibitor MDL28170 has previously shown anti-Leishmania activity, therefore its use in association with standard drug...

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Detalles Bibliográficos
Autores principales: Branquinha, Marta H., Araújo, Pedro S. S., Oliveira, Simone S. C., Sangenito, Leandro S., Gonçalves, Diego S., Seabra, Sérgio H., d’Avila-Levy, Claudia M., Santos, André L. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878347/
https://www.ncbi.nlm.nih.gov/pubmed/35202224
http://dx.doi.org/10.3390/tropicalmed7020029