ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection

The Gram-negative, opportunistic pathogen Pseudomonas aeruginosa utilizes a type III secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied exoenzymes, ExoU causes rapid cell damage and death. ExoU is a phospholipase A(2) (PLA(2)) that hydrolyses host cell m...

Descripción completa

Detalles Bibliográficos
Autores principales: Hardy, Kierra S., Tuckey, Amanda N., Renema, Phoibe, Patel, Mita, Al-Mehdi, Abu-Bakr, Spadafora, Domenico, Schlumpf, Cody A., Barrington, Robert A., Alexeyev, Mikhail F., Stevens, Troy, Pittet, Jean-Francois, Wagener, Brant M., Simmons, Jon D., Alvarez, Diego F., Audia, Jonathon P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878379/
https://www.ncbi.nlm.nih.gov/pubmed/35202178
http://dx.doi.org/10.3390/toxins14020152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878379/
https://www.ncbi.nlm.nih.gov/pubmed/35202178
http://dx.doi.org/10.3390/toxins14020152

Ejemplares similares