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ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection

The Gram-negative, opportunistic pathogen Pseudomonas aeruginosa utilizes a type III secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied exoenzymes, ExoU causes rapid cell damage and death. ExoU is a phospholipase A(2) (PLA(2)) that hydrolyses host cell m...

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Detalles Bibliográficos
Autores principales:	Hardy, Kierra S., Tuckey, Amanda N., Renema, Phoibe, Patel, Mita, Al-Mehdi, Abu-Bakr, Spadafora, Domenico, Schlumpf, Cody A., Barrington, Robert A., Alexeyev, Mikhail F., Stevens, Troy, Pittet, Jean-Francois, Wagener, Brant M., Simmons, Jon D., Alvarez, Diego F., Audia, Jonathon P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878379/ https://www.ncbi.nlm.nih.gov/pubmed/35202178 http://dx.doi.org/10.3390/toxins14020152

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