Targeting Apoptosis Pathways With BCL2 and MDM2 Inhibitors in Adult B-cell Acute Lymphoblastic Leukemia

In adult patients, the treatment outcome of acute lymphoblastic leukemia (ALL) remains suboptimal. Here, we used an ex vivo drug testing platform and comprehensive molecular profiling to discover new drug candidates for B-ALL. We analyzed sensitivity of 18 primary B-ALL adult patient samples to 64 d...

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Detalles Bibliográficos
Autores principales: Hohtari, Helena, Kankainen, Matti, Adnan-Awad, Shady, Yadav, Bhagwan, Potdar, Swapnil, Ianevski, Aleksandr, Dufva, Olli, Heckman, Caroline, Sexl, Veronika, Kytölä, Soili, Mustjoki, Satu, Porkka, Kimmo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878725/
https://www.ncbi.nlm.nih.gov/pubmed/35233509
http://dx.doi.org/10.1097/HS9.0000000000000701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878725/
https://www.ncbi.nlm.nih.gov/pubmed/35233509
http://dx.doi.org/10.1097/HS9.0000000000000701

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