A Unique Core–Shell Structured, Glycol Chitosan-Based Nanoparticle Achieves Cancer-Selective Gene Delivery with Reduced Off-Target Effects

The inherent instability of nucleic acids within serum and the tumor microenvironment necessitates a suitable vehicle for non-viral gene delivery to malignant lesions. A specificity-conferring mechanism is also often needed to mitigate off-target toxicity. In the present study, we report a stable an...

Descripción completa

Detalles Bibliográficos
Autores principales: Cheng, Bei, Ahn, Hye-Hyun, Nam, Hwanhee, Jiang, Zirui, Gao, Feng J., Minn, Il, Pomper, Martin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878887/
https://www.ncbi.nlm.nih.gov/pubmed/35214105
http://dx.doi.org/10.3390/pharmaceutics14020373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8878887/
https://www.ncbi.nlm.nih.gov/pubmed/35214105
http://dx.doi.org/10.3390/pharmaceutics14020373

Ejemplares similares