Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice

Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein implicated in various functions, including metabolism, tissue regeneration, and functional homeostasis. SPARC/Sparc declines with ageing but increases with exercise. We aim to verify two hypotheses: (1) SPARC defici...

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Detalles Bibliográficos
Autores principales: Ghanemi, Abdelaziz, Melouane, Aicha, Yoshioka, Mayumi, St-Amand, Jonny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879002/
https://www.ncbi.nlm.nih.gov/pubmed/35208200
http://dx.doi.org/10.3390/metabo12020125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879002/
https://www.ncbi.nlm.nih.gov/pubmed/35208200
http://dx.doi.org/10.3390/metabo12020125

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