Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy

The surface of Ti(3)C(2) MXene nanosheets (TC NSs) was first modified with the antioxidants sodium ascorbate (SA) and dopamine (DA) (DSTC NS) to improve their stability in oxidative and hydration environments and thereby improve their bioapplications. This novel approach not only improved MXene stab...

Descripción completa

Detalles Bibliográficos
Autores principales: Korupalli, Chiranjeevi, You, Kai-Long, Getachew, Girum, Rasal, Akash S., Dirersa, Worku Batu, Zakki Fahmi, Mochamad, Chang, Jia-Yaw
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879045/
https://www.ncbi.nlm.nih.gov/pubmed/35214033
http://dx.doi.org/10.3390/pharmaceutics14020304
_version_ 1784658805098807296
author Korupalli, Chiranjeevi
You, Kai-Long
Getachew, Girum
Rasal, Akash S.
Dirersa, Worku Batu
Zakki Fahmi, Mochamad
Chang, Jia-Yaw
author_facet Korupalli, Chiranjeevi
You, Kai-Long
Getachew, Girum
Rasal, Akash S.
Dirersa, Worku Batu
Zakki Fahmi, Mochamad
Chang, Jia-Yaw
author_sort Korupalli, Chiranjeevi
collection PubMed
description The surface of Ti(3)C(2) MXene nanosheets (TC NSs) was first modified with the antioxidants sodium ascorbate (SA) and dopamine (DA) (DSTC NS) to improve their stability in oxidative and hydration environments and thereby improve their bioapplications. This novel approach not only improved MXene stability by arresting oxidation but also increased the available functional groups for further functionalization with various biomolecules. The DSTC NSs were then sequentially conjugated with enzyme glucose oxidase (GOx) and photosensitizer Ce6 to render the obtained CGDSTC NSs with glucose starvation and photodynamic therapeutic properties and thus attain high efficiency in killing cancer cells through the cooperative effect. The as-synthesized CGDSTC NSs demonstrated tremendous photothermal effect with conversion efficiency of 45.1% and photodynamic (ROS generation) properties upon irradiation with 808 and 671 nm lasers. Furthermore, it was observed that the enzymatic activity of CGDSTC NSs increased upon laser irradiation due to enhanced solution temperature. During in vitro studies, the CGDSTC NSs exhibited cytocompatability to HePG2 and HeLa cells under nonstimulus conditions. However, they elicited more than 90% cell-killing efficiency in the presence of glucose and laser irradiation via the cooperative effect between starvation therapy and phototherapy. These results indicate that CGDSTC NSs could be used as potential therapeutic agents to eradicate cancers with no or few adverse effects. This surface modification approach is also simple and facile to adopt in MXene-based research.
format Online
Article
Text
id pubmed-8879045
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-88790452022-02-26 Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy Korupalli, Chiranjeevi You, Kai-Long Getachew, Girum Rasal, Akash S. Dirersa, Worku Batu Zakki Fahmi, Mochamad Chang, Jia-Yaw Pharmaceutics Article The surface of Ti(3)C(2) MXene nanosheets (TC NSs) was first modified with the antioxidants sodium ascorbate (SA) and dopamine (DA) (DSTC NS) to improve their stability in oxidative and hydration environments and thereby improve their bioapplications. This novel approach not only improved MXene stability by arresting oxidation but also increased the available functional groups for further functionalization with various biomolecules. The DSTC NSs were then sequentially conjugated with enzyme glucose oxidase (GOx) and photosensitizer Ce6 to render the obtained CGDSTC NSs with glucose starvation and photodynamic therapeutic properties and thus attain high efficiency in killing cancer cells through the cooperative effect. The as-synthesized CGDSTC NSs demonstrated tremendous photothermal effect with conversion efficiency of 45.1% and photodynamic (ROS generation) properties upon irradiation with 808 and 671 nm lasers. Furthermore, it was observed that the enzymatic activity of CGDSTC NSs increased upon laser irradiation due to enhanced solution temperature. During in vitro studies, the CGDSTC NSs exhibited cytocompatability to HePG2 and HeLa cells under nonstimulus conditions. However, they elicited more than 90% cell-killing efficiency in the presence of glucose and laser irradiation via the cooperative effect between starvation therapy and phototherapy. These results indicate that CGDSTC NSs could be used as potential therapeutic agents to eradicate cancers with no or few adverse effects. This surface modification approach is also simple and facile to adopt in MXene-based research. MDPI 2022-01-27 /pmc/articles/PMC8879045/ /pubmed/35214033 http://dx.doi.org/10.3390/pharmaceutics14020304 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Korupalli, Chiranjeevi
You, Kai-Long
Getachew, Girum
Rasal, Akash S.
Dirersa, Worku Batu
Zakki Fahmi, Mochamad
Chang, Jia-Yaw
Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy
title Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy
title_full Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy
title_fullStr Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy
title_full_unstemmed Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy
title_short Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy
title_sort engineering the surface of ti(3)c(2) mxene nanosheets for high stability and multimodal anticancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879045/
https://www.ncbi.nlm.nih.gov/pubmed/35214033
http://dx.doi.org/10.3390/pharmaceutics14020304
work_keys_str_mv AT korupallichiranjeevi engineeringthesurfaceofti3c2mxenenanosheetsforhighstabilityandmultimodalanticancertherapy
AT youkailong engineeringthesurfaceofti3c2mxenenanosheetsforhighstabilityandmultimodalanticancertherapy
AT getachewgirum engineeringthesurfaceofti3c2mxenenanosheetsforhighstabilityandmultimodalanticancertherapy
AT rasalakashs engineeringthesurfaceofti3c2mxenenanosheetsforhighstabilityandmultimodalanticancertherapy
AT dirersaworkubatu engineeringthesurfaceofti3c2mxenenanosheetsforhighstabilityandmultimodalanticancertherapy
AT zakkifahmimochamad engineeringthesurfaceofti3c2mxenenanosheetsforhighstabilityandmultimodalanticancertherapy
AT changjiayaw engineeringthesurfaceofti3c2mxenenanosheetsforhighstabilityandmultimodalanticancertherapy