Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy
The surface of Ti(3)C(2) MXene nanosheets (TC NSs) was first modified with the antioxidants sodium ascorbate (SA) and dopamine (DA) (DSTC NS) to improve their stability in oxidative and hydration environments and thereby improve their bioapplications. This novel approach not only improved MXene stab...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879045/ https://www.ncbi.nlm.nih.gov/pubmed/35214033 http://dx.doi.org/10.3390/pharmaceutics14020304 |
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author | Korupalli, Chiranjeevi You, Kai-Long Getachew, Girum Rasal, Akash S. Dirersa, Worku Batu Zakki Fahmi, Mochamad Chang, Jia-Yaw |
author_facet | Korupalli, Chiranjeevi You, Kai-Long Getachew, Girum Rasal, Akash S. Dirersa, Worku Batu Zakki Fahmi, Mochamad Chang, Jia-Yaw |
author_sort | Korupalli, Chiranjeevi |
collection | PubMed |
description | The surface of Ti(3)C(2) MXene nanosheets (TC NSs) was first modified with the antioxidants sodium ascorbate (SA) and dopamine (DA) (DSTC NS) to improve their stability in oxidative and hydration environments and thereby improve their bioapplications. This novel approach not only improved MXene stability by arresting oxidation but also increased the available functional groups for further functionalization with various biomolecules. The DSTC NSs were then sequentially conjugated with enzyme glucose oxidase (GOx) and photosensitizer Ce6 to render the obtained CGDSTC NSs with glucose starvation and photodynamic therapeutic properties and thus attain high efficiency in killing cancer cells through the cooperative effect. The as-synthesized CGDSTC NSs demonstrated tremendous photothermal effect with conversion efficiency of 45.1% and photodynamic (ROS generation) properties upon irradiation with 808 and 671 nm lasers. Furthermore, it was observed that the enzymatic activity of CGDSTC NSs increased upon laser irradiation due to enhanced solution temperature. During in vitro studies, the CGDSTC NSs exhibited cytocompatability to HePG2 and HeLa cells under nonstimulus conditions. However, they elicited more than 90% cell-killing efficiency in the presence of glucose and laser irradiation via the cooperative effect between starvation therapy and phototherapy. These results indicate that CGDSTC NSs could be used as potential therapeutic agents to eradicate cancers with no or few adverse effects. This surface modification approach is also simple and facile to adopt in MXene-based research. |
format | Online Article Text |
id | pubmed-8879045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-88790452022-02-26 Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy Korupalli, Chiranjeevi You, Kai-Long Getachew, Girum Rasal, Akash S. Dirersa, Worku Batu Zakki Fahmi, Mochamad Chang, Jia-Yaw Pharmaceutics Article The surface of Ti(3)C(2) MXene nanosheets (TC NSs) was first modified with the antioxidants sodium ascorbate (SA) and dopamine (DA) (DSTC NS) to improve their stability in oxidative and hydration environments and thereby improve their bioapplications. This novel approach not only improved MXene stability by arresting oxidation but also increased the available functional groups for further functionalization with various biomolecules. The DSTC NSs were then sequentially conjugated with enzyme glucose oxidase (GOx) and photosensitizer Ce6 to render the obtained CGDSTC NSs with glucose starvation and photodynamic therapeutic properties and thus attain high efficiency in killing cancer cells through the cooperative effect. The as-synthesized CGDSTC NSs demonstrated tremendous photothermal effect with conversion efficiency of 45.1% and photodynamic (ROS generation) properties upon irradiation with 808 and 671 nm lasers. Furthermore, it was observed that the enzymatic activity of CGDSTC NSs increased upon laser irradiation due to enhanced solution temperature. During in vitro studies, the CGDSTC NSs exhibited cytocompatability to HePG2 and HeLa cells under nonstimulus conditions. However, they elicited more than 90% cell-killing efficiency in the presence of glucose and laser irradiation via the cooperative effect between starvation therapy and phototherapy. These results indicate that CGDSTC NSs could be used as potential therapeutic agents to eradicate cancers with no or few adverse effects. This surface modification approach is also simple and facile to adopt in MXene-based research. MDPI 2022-01-27 /pmc/articles/PMC8879045/ /pubmed/35214033 http://dx.doi.org/10.3390/pharmaceutics14020304 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Korupalli, Chiranjeevi You, Kai-Long Getachew, Girum Rasal, Akash S. Dirersa, Worku Batu Zakki Fahmi, Mochamad Chang, Jia-Yaw Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy |
title | Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy |
title_full | Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy |
title_fullStr | Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy |
title_full_unstemmed | Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy |
title_short | Engineering the Surface of Ti(3)C(2) MXene Nanosheets for High Stability and Multimodal Anticancer Therapy |
title_sort | engineering the surface of ti(3)c(2) mxene nanosheets for high stability and multimodal anticancer therapy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879045/ https://www.ncbi.nlm.nih.gov/pubmed/35214033 http://dx.doi.org/10.3390/pharmaceutics14020304 |
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