Ribozyme Assays to Quantify the Capping Efficiency of In Vitro-Transcribed mRNA

The presence of the cap structure on the 5′-end of in vitro-transcribed (IVT) mRNA determines its translation and stability, underpinning its use in therapeutics. Both enzymatic and co-transcriptional capping may lead to incomplete positioning of the cap on newly synthesized RNA molecules. IVT mRNAs...

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Detalles Bibliográficos
Autores principales: Vlatkovic, Irena, Ludwig, János, Boros, Gábor, Szabó, Gábor Tamás, Reichert, Julia, Buff, Maximilian, Baiersdörfer, Markus, Reinholz, Jonas, Mahiny, Azita Josefine, Şahin, Uğur, Karikó, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879150/
https://www.ncbi.nlm.nih.gov/pubmed/35214060
http://dx.doi.org/10.3390/pharmaceutics14020328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879150/
https://www.ncbi.nlm.nih.gov/pubmed/35214060
http://dx.doi.org/10.3390/pharmaceutics14020328

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