Delivery of Oligonucleotides: Efficiency with Lipid Conjugation and Clinical Outcome

Oligonucleotides have shifted drug discovery into a new paradigm due to their ability to silence the genes and inhibit protein translation. Importantly, they can drug the un-druggable targets from the conventional small-molecule perspective. Unfortunately, poor cellular permeability and susceptibili...

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Detalles Bibliográficos
Autores principales: Tran, Phuc, Weldemichael, Tsigereda, Liu, Zhichao, Li, Hong-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879684/
https://www.ncbi.nlm.nih.gov/pubmed/35214074
http://dx.doi.org/10.3390/pharmaceutics14020342

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879684/
https://www.ncbi.nlm.nih.gov/pubmed/35214074
http://dx.doi.org/10.3390/pharmaceutics14020342

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