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Delivery of Oligonucleotides: Efficiency with Lipid Conjugation and Clinical Outcome
Oligonucleotides have shifted drug discovery into a new paradigm due to their ability to silence the genes and inhibit protein translation. Importantly, they can drug the un-druggable targets from the conventional small-molecule perspective. Unfortunately, poor cellular permeability and susceptibili...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879684/ https://www.ncbi.nlm.nih.gov/pubmed/35214074 http://dx.doi.org/10.3390/pharmaceutics14020342 |