A Conserved Receptor-Binding Domain in the VP1u of Primate Erythroparvoviruses Determines the Marked Tropism for Erythroid Cells

Parvovirus B19 (B19V) is a human pathogen with a marked tropism for erythroid progenitor cells (EPCs). The N-terminal of the VP1 unique region (VP1u) contains a receptor-binding domain (RBD), which mediates virus uptake through interaction with an as-yet-unknown receptor (VP1uR). Considering the cen...

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Detalles Bibliográficos
Autores principales: Bircher, Cornelia, Bieri, Jan, Assaraf, Ruben, Leisi, Remo, Ros, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879732/
https://www.ncbi.nlm.nih.gov/pubmed/35216013
http://dx.doi.org/10.3390/v14020420

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879732/
https://www.ncbi.nlm.nih.gov/pubmed/35216013
http://dx.doi.org/10.3390/v14020420

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