Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1

Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1), enhancing viral infectivity and entry into the cell. Here we report the identification of 20 small-molecule inhibitors t...

Descripción completa

Detalles Bibliográficos
Autores principales: Kolarič, Anja, Jukič, Marko, Bren, Urban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879887/
https://www.ncbi.nlm.nih.gov/pubmed/35215277
http://dx.doi.org/10.3390/ph15020165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879887/
https://www.ncbi.nlm.nih.gov/pubmed/35215277
http://dx.doi.org/10.3390/ph15020165

Ejemplares similares