Combined Administration of (R)-Ketamine and the mGlu2/3 Receptor Antagonist LY341495 Induces Rapid and Sustained Effects in the CUMS Model of Depression via a TrkB/BDNF-Dependent Mechanism

Ketamine is an effective, rapid-acting antidepressant drug (RAAD), but it induces side effects. To overcome these challenges, attempts have been made to use safer enantiomer ((R)-ketamine) or mGlu2/3 receptor antagonists, which induce ketamine-like effects and enhance its action. Here, we propose co...

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Detalles Bibliográficos
Autores principales: Rafało-Ulińska, Anna, Brański, Piotr, Pałucha-Poniewiera, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879988/
https://www.ncbi.nlm.nih.gov/pubmed/35215237
http://dx.doi.org/10.3390/ph15020125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879988/
https://www.ncbi.nlm.nih.gov/pubmed/35215237
http://dx.doi.org/10.3390/ph15020125

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