Hepatic CYP3A4 Enzyme Compensatively Maintains Endogenous Geranylgeranoic Acid Levels in MAOB-Knockout Human Hepatoma Cells

Geranylgeranoic acid (GGA), developed as a preventive agent against second primary hepatoma, has been reported to be biosynthesized via the mevalonate pathway in human hepatoma-derived cells. Recently, we found that monoamine oxidase B (MAOB) catalyzed the oxidation of geranylgeraniol (GGOH) to prod...

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Detalles Bibliográficos
Autores principales: Tabata, Yuki, Shidoji, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880059/
https://www.ncbi.nlm.nih.gov/pubmed/35208214
http://dx.doi.org/10.3390/metabo12020140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880059/
https://www.ncbi.nlm.nih.gov/pubmed/35208214
http://dx.doi.org/10.3390/metabo12020140

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